ParkinsonCanadaV1, Main, Exploration, bibRecord, 000C19

α-Synuclein Membrane Association Is Regulated by the Rab3a Recycling Machinery and Presynaptic Activity*♦

Identifieur interne : 000C19 ( Main/Exploration ); précédent : 000C18; suivant : 000C20

α-Synuclein Membrane Association Is Regulated by the Rab3a Recycling Machinery and Presynaptic Activity*♦

Auteurs : Robert H. C. Chen ; Sabine Wislet-Gendebien ; Filsy Samuel ; Naomi P. Visanji ; Gang Zhang ; Diana Marsilio ; Tammy Langman ; Paul E. Fraser ; Anurag Tandon [Canada]

Source :

The Journal of Biological Chemistry [ 0021-9258 ] ; 2013.

RBID : PMC:3597785

English descriptors

KwdEn :
- Animals, Brain (metabolism), Cell Line, Tumor, Cell Membrane (metabolism), Cytosol (metabolism), Epitopes (chemistry), Glycerol (chemistry), Guanosine Triphosphate (metabolism), HSP90 Heat-Shock Proteins (metabolism), Humans, Mice, Mice, Transgenic, Models, Biological, Neurodegenerative Diseases (metabolism), Neurons (metabolism), Subcellular Fractions (metabolism), Synapses (metabolism), Synaptosomes (metabolism), alpha-Synuclein (chemistry), alpha-Synuclein (metabolism), rab3A GTP-Binding Protein (metabolism).
MESH :
- chemical , chemistry : Epitopes, Glycerol, alpha-Synuclein.
- metabolism : Brain, Cell Membrane, Cytosol, Guanosine Triphosphate, HSP90 Heat-Shock Proteins, Neurodegenerative Diseases, Neurons, Subcellular Fractions, Synapses, Synaptosomes, alpha-Synuclein, rab3A GTP-Binding Protein.
- Animals, Cell Line, Tumor, Humans, Mice, Mice, Transgenic, Models, Biological.

Abstract

Background: α-Synuclein is known to undergo exchange between membrane and cytosolic compartments.

Results: α-Synuclein interacts with GTP-bound Rab3a on synaptic vesicles, and its dissociation is mediated by GDI/Hsp90.

Conclusion: α-Synuclein's membrane association and dissociation cycle is linked to synaptic activity by the Rab3a recycling machinery.

Significance: Significance: Impairments to α-synuclein interactions with vesicles and with the Rab3a recycling machinery may affect neurodegeneration.

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3597785

DOI: 10.1074/jbc.M112.439497
PubMed: 23344955
PubMed Central: 3597785

Affiliations:

Le document en format XML

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<author><name sortKey="Chen, Robert H C" sort="Chen, Robert H C" uniqKey="Chen R" first="Robert H. C." last="Chen">Robert H. C. Chen</name>
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<series><title level="j">The Journal of Biological Chemistry</title>
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<term>alpha-Synuclein (metabolism)</term>
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<term>Glycerol</term>
<term>alpha-Synuclein</term>
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<term>Cell Membrane</term>
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<term>Guanosine Triphosphate</term>
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<term>Synaptosomes</term>
<term>alpha-Synuclein</term>
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<term>Cell Line, Tumor</term>
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<front><div type="abstract" xml:lang="en"><p><bold>Background:</bold>
 α-Synuclein is known to undergo exchange between membrane and cytosolic compartments.</p>
<p><bold>Results:</bold>
 α-Synuclein interacts with GTP-bound Rab3a on synaptic vesicles, and its dissociation is mediated by GDI/Hsp90.</p>
<p><bold>Conclusion:</bold>
 α-Synuclein's membrane association and dissociation cycle is linked to synaptic activity by the Rab3a recycling machinery.</p>
<p><bold>Significance:</bold>
 Significance: Impairments to α-synuclein interactions with vesicles and with the Rab3a recycling machinery may affect neurodegeneration.</p>
</div>
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<name sortKey="Visanji, Naomi P" sort="Visanji, Naomi P" uniqKey="Visanji N" first="Naomi P." last="Visanji">Naomi P. Visanji</name>
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La maladie de Parkinson au Canada (serveur d'exploration)

α-Synuclein Membrane Association Is Regulated by the Rab3a Recycling Machinery and Presynaptic Activity*♦

α-Synuclein Membrane Association Is Regulated by the Rab3a Recycling Machinery and Presynaptic Activity*♦

Source :

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

Pour générer des pages wiki

	La maladie de Parkinson au Canada (serveur d'exploration)
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